As a leader in nutritional medicine, Jeffrey S. Bland, PhD, FACN, CNS, is well known for his synthesis of medical knowledge, biochemistry, and nutritional data. Treating chronic illness and patients with multiple comorbidities requires a systems-based approach, yet treatments must also be tailored to each individual. Dr. Bland describes why this is necessary, how it can be enacted, and what clinicians can do to implement this type of methodology.